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NCE-1 Intelligence & Market Opportunity

Idvynso

Doravirine And Islatravir
Antiretroviral (ARV) Agent
Oral Tablet

Idvynso is a prescription oral therapy indicated as a complete regimen for the treatment of HIV-1 infection in adults who are already virologically suppressed on a stable antiretroviral regimen. Designed to replace an existing treatment in patients with no history of virologic failure and no known resistance to Doravirine, a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). As a switch therapy, Idvynso offers a streamlined, once-daily oral regimen aimed at maintaining viral suppression while potentially improving treatment adherence and tolerability.

By leveraging the potency and resistance profile of doravirine, Idvynso supports long-term HIV management with a simplified approach for eligible patients. It is particularly relevant in treatment-experienced individuals seeking regimen optimization without compromising efficacy. As with all antiretroviral therapies, careful patient selection, resistance assessment, and ongoing clinical monitoring are essential to ensure sustained viral suppression and minimize the risk of treatment failure.

Approval Date
20-Apr-26
NCE-1 Date
20-Apr-30
NCE Date
20-Apr-31
Commercial snapshot

Market performance & projections

Revenue ($M)
NA
CAGR (%)
NA
Projected sales, 2026–2032 ($M)
Analyst projection, $M per year
2026
383
2027
577
2028
777
2029
964
2030
1164
2031
1354
2032
1558
Molecule profile

Details & specifications

Molecule
Doravirine And Islatravir
Innovator
MERCK SHARP & DOHME LLC
Dosage Form
Oral Tablet
Strength
100 mg/0.25 mg
Therapeutic Category
Antiretroviral (ARV) Agent
Usage
To treat HIV-1 infection (as a complete regimen) in adults to replace the current antiretroviral regimen in those who are virologically-suppressed on a stable antiretroviral regimen with no history of virologic treatment failure and no known substitutions associated with resistance to doravirine
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