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Brand Name	Brand Name Slug	Molecule	Molecule Slug	Approval Date	NCE Date	NCE-1 Date	Innovator	Dosage Form	Strength	Therapeutic Category	Usage	Revenue ($M)	Projected Sales By 2025 ($M)	Projected Sales By 2026 ($M)	Projected Sales By 2027 ($M)	Projected Sales By 2028 ($M)	Projected Sales By 2029 ($M)	Projected Sales By 2030 ($M)	Projected Sales By 2031 ($M)	CAGR (%)	Description	Question 1	Answer 1	Question 2	Answer 2	Question 3	Answer 3	Question 4	Answer 4
Brenzavvy	brenzavvy	Bexagliflozin	bexagliflozin	20-Jan-23	20-Jan-28	20-Jan-27	THERACOSBIO LLC	Tablet	20mg	Antidiabetic	To Improve Glycemic Control In Adults With Type 2 Diabetes Mellitus As An Adjunct To Diet And Exercise	NA	663	764	845	928	1,015	NA	NA	NA	Brenzavvy is an SGLT2 inhibitor that helps lower your average blood sugar level over 90 to 120 days. Itâs FDA-approved to be used alongside diet and exercise to manage blood sugar in adults with type 2 diabetes.	Who might benefit from taking Brenzavvy?	Adults with type 2 diabetes who are looking to improve their blood sugar control alongside diet and exercise may benefit from Brenzavvy.	What are the common side effects of Brenzavvy?	Common side effects may include urinary tract infections, increased urination, and genital yeast infections.	What is the generic for Brenzavvy?	Bexagliflozin is the generic for Brenzavvy	Are there any precautions or interactions while taking Brenzavvy?	Brenzavvy may interact with certain medications affecting kidney function. It's important to inform your healthcare provider about all the medications you're taking.
Jaypirca	jaypirca	Pirtobrutinib	pirtobrutinib	27-Jan-23	27-Jan-28	27-Jan-27	LOXO ONCOLOGY INC	Tablet	50mg,100mg	Anticancer	To Treat Relapsed Or Refractory Mantle Cell Lymphoma In Adults Who Have Had At Least Two Lines Of Systemic Therapy, Including A BTK Inhibitor	337	606	891	1,177	1,464	1,928	2,332	2,760	44.37%	Jaypirca is a non-covalent BTK inhibitor used to treat adults with relapsed or refractory mantle cell lymphoma and chronic lymphocytic leukemia after prior treatments. Itâs taken orally once daily.	What are the common side effects of Jaypirca?	Common side effects of Jaypirca may include diarrhea, fatigue, and upper respiratory tract infections.	How does Jaypirca work differently from other BTK inhibitors?	Jaypirca is a non-covalent (reversible) Brutonâs tyrosine kinase (BTK) inhibitor. This means that it continues to work even when cancer cells develop resistance to traditional covalent BTK inhibitors.
Orserdu	orserdu	Elacestrant	elacestrant	27-Jan-23	27-Jan-28	27-Jan-27	STEMLINE THERAPEUTICS INC	Tablet	EQ 86MG BASE,EQ 345MG BASE	Hormonal Therapy	To Treat Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative, ESR1-Mutated, Advanced Or Metastatic Breast Cancer With Disease Progression Following At Least One Line Of Endocrine Therapy	NA	6	28	58	98	139	174	212	NA	Orserdu is a once-daily selective estrogen receptor degrader (SERD) approved for ER-positive, HER2-negative, ESR1-mutated, advanced or metastatic breast cancer in adults after endocrine therapy.
Jesduvroq	jesduvroq	Daprodustat	daprodustat	01-Feb-23	01-Feb-28	01-Feb-27	GLAXOSMITHKLINE INTELLECTUAL PROPERTY NO 2 LTD ENGLAND	Tablet	1mg,2mg,4mg,6mg,8mg	Antianemic	To Treat Anemia Caused By Chronic Kidney Disease For Adults On Dialysis For At Least Four Months	NA	72	107	134	157	174	185	192	NA	Jesduvroq is an oral HIF-PHI approved for the treatment of anemia in adults with chronic kidney disease on dialysis. It was voluntarily withdrawn in the U.S. for non-safety-related reasons but remains FDA-listed.
Filspari	filspari	Sparsentan	sparsentan	17-Feb-23	17-Feb-28	17-Feb-27	TRAVERE THERAPEUTICS	Tablet	200 mg and 400 mg	Antiproteinuric	To Reduce Proteinuria In Adults With Primary Immunoglobulin	132	295	434	643	810	993	1,189	1,386	57.39%	Filspari is an oral dual endothelin and angiotensin receptor blocker approved to reduce proteinuria and slow kidney function decline in adults with IgA nephropathy.
Skyclarys	skyclarys	Omaveloxolone	omaveloxolone	28-Feb-23	28-Feb-28	28-Feb-27	REATA PHARMACEUTICALS INC	Capsule	50mg	Neuroprotective	For The Treatment Of Friedreich Ataxia In Adults And Children 16 Years Of Age And Older.	383	526	672	791	908	1,014	1,089	1,148	24.09%	Skyclarys is the first FDA-approved treatment for Friedreichâs ataxia in patients aged 16 years and older. It helps reduce physical impairment associated with the condition.
Zavzpret	zavzpret	Zavegepant	zavegepant	09-Mar-23	09-Mar-28	09-Mar-27	PFIZER INC	Nasal Spray	10MG BASE/SPRAY	Antimigraine	Acute Treatment Of Migraine With Or Without Aura In Adults.	NA	185	248	300	334	366	396	417	NA	Zavzpret is a fast-acting nasal spray for the acute treatment of migraine in adults. It provides pain relief and functional recovery, with effects starting as early as 30 minutes after use.
Daybue	daybue	Trofinetide	trofinetide	10-Mar-23	10-Mar-28	10-Mar-27	ACADIA PHARMACEUTICALS INC	Oral Solution	200mg/ml	Neuroprotective	To Treat Rett Syndrome In Adults And Children 2 Years And Older.	348	389	469	536	605	658	710	763	14.83%	Daybue is the first FDA-approved oral treatment for Rett syndrome in patients 2 years of age and older. It targets neurological function to address core symptoms of the disorder.
Rezzayo	rezzayo	Rezafungin Acetate	rezafungin-acetate	22-Mar-23	22-Mar-28	22-Mar-27	CIDARA THERAPEUTICS INC	Injection- IV	200MG BASE/VIAL	Antifungal	To Treat Candidemia And Invasive Candidiasis	NA	18	35	54	69	79	92	NA	NA	Rezzayo is the first new echinocandin antifungal approved by the FDA in over 15 years for adults with limited or no alternative options for treating candidemia and invasive candidiasis. It works by inhibiting fungal Î²-glucan synthase, thereby disrupting cell wall synthesis, and simplifying care with once-weekly intravenous dosing.
Joenja	joenja	Leniolisib	leniolisib	24-Mar-23	24-Mar-28	24-Mar-27	PHARMING TECHNOLOGIES BV	Tablet	70MG	Immunomodulators	To Treat Activated Phosphoinositide 3-Kinase Delta Syndrome	45	64	103	147	189	232	273	316	43.16%	Joenja is the first FDAâapproved oral selective PI3KÎ´ inhibitor for activated phosphoinositide 3âkinase delta (PI3KÎ´) syndrome (APDS). It is administered to patients aged 12 years and older, targeting the underlying immune signaling defect in APDS to address both immunodeficiency and immune dysregulation.
Qalsody	qalsody	Tofersen	tofersen	25-Apr-23	25-Apr-28	25-Apr-27	BIOGEN MA INC	Solution Intraethical	100MG/15ML (6.7MG/ML)	Neuroprotective	To Treat Amyotrophic Lateral Sclerosis In Adults Who Have A SOD1 Gene Mutation	32	79	105	124	140	140	148	157	44.63%	Qalsody is the first FDAâapproved antisense oligonucleotide treatment for amyotrophic lateral sclerosis (ALS) associated with SOD1 gene mutations. It reduces SOD1 protein synthesis by targeting SOD1 mRNA, addressing disease progression at a genetic level.
Veozah	veozah	Fezolinetant	fezolinetant	12-May-23	12-May-28	12-May-27	ASTELLAS PHARMA US INC	Tablet	45MG	Anti-Menopausal	To Treat Moderate To Severe Hot Flashes Caused By Menopause	222	331	446	578	707	836	953	1,053	33.59%	Veozah is the first FDAâapproved nonâhormonal oral neurokinin 3 (NK3) receptor antagonist for moderate to severe vasomotor symptoms (hot flashes and night sweats) due to menopause. It blocks neurokinin B activity in the hypothalamus to regulate body temperature without estrogen .
Miebo	miebo	Perfluorhexyloctane	perfluorhexyloctane	18-May-23	18-May-28	18-May-27	BAUSCH AND LOMB INC	Eye Drops	1.338GM/ML	Ophthalmic	To Treat Signs And Symptoms Of Dry Eye Disease	NA	116	201	309	413	NA	NA	NA	NA	Miebo is an eye drop that treats dry eye disease by reducing tear evaporation. It forms a protective layer on the eye to keep it moist and comfortable.
Xacduro	xacduro	Sulbactam And Durlobactam	sulbactam-and-durlobactam	23-May-23	23-May-28	23-May-27	ENTASIS THERAPEUTICS INC	IV Injection	EQ 500MG BASE/VIAL; EQ 500MG BASE/VIAL; EQ 1GM BASE/VIAL	Antibiotic	To Treat Hospital-Acquired Bacterial Pneumonia And Ventilator-Associated Bacterial Pneumonia Caused By Susceptible Isolates Of Acinetobacter Baumannii-Calcoaceticus Complex	24	51	109	186	258	334	382	438	81.07%	Xacduro is an IV antibiotic used for serious lung infections caused by resistant Acinetobacter bacteria. It combines two medicines to fight tough infections effectively.
Paxlovid	paxlovid	Nirmatrelvir And Ritonavir	nirmatrelvir-and-ritonavir	25-May-23	25-May-28	25-May-27	PFIZER INC	Tablet	150MG;100MG; 300MG; 100MG	Antiviral	To Treat Mild-To-Moderate COVID-19 In Adults At High Risk For Progression To Severe COVID-19	5,716	3,916	3,800	3,675	3,526	3,401	3,277	3,147	-11.38%	Paxlovid is an oral treatment for mild to moderate COVID-19 in high-risk patients. It stops the virus from multiplying and helps prevent severe illness when taken early.
Posluma	posluma	Flotufolastat F 18	flotufolastat-f-18	25-May-23	25-May-28	25-May-27	BLUE EARTH DIAGNOSTICS LTD	Intravenous Solution	25ML (8-158mCi/ML)	Diagnostic Agents	To Use With Positron Emission Tomography Imaging In Certain Patients With Prostate Cancer	NA	NA	NA	NA	NA	NA	NA	NA	NA	Posluma is a PSMA-targeted PET imaging agent used in prostate cancer. It helps doctors detect and locate primary and metastatic prostate tumors more accurately using a novel radiohybrid compound.
Inpefa	inpefa	Sotagliflozin	sotagliflozin	26-May-23	26-May-28	26-May-27	LEXICON PHARMACEUTICALS INC	Tablet	200mg, 400mg	Cardiovascular Agents	To Treat Heart Failure	6	6	12	28	58	98	145	185	76.33%	Inpefa is a once-daily oral tablet for adults with heart failure, with or without type 2 diabetes or kidney disease. It reduces the risk of cardiovascular death, hospitalization, or urgent heart failure visits.
Litfulo	litfulo	Ritlecitinib	ritlecitinib	23-Jun-23	23-Jun-28	23-Jun-27	PFIZER INC	Capsule	50MG	Immunomodulators	To Treat Severely Patchy Hair Loss	NA	113	185	264	350	423	489	540	NA	Litfulo is an oral treatment for adults and adolescents aged 12 and older with severe alopecia areata. It helps regrow scalp hair by blocking immune pathways that attack hair follicles.
Vanflyta	vanflyta	Quizartinib	quizartinib	20-Jul-23	20-Jul-28	20-Jul-27	DAIICHI SANKYO INC	Tablet	17.7mg and 26.5 mg base	Anticancer	To Use As Part Of A Treatment Regimen For Newly Diagnosed Acute Myeloid Leukemia That Meets Certain Criteria	30	55	73	95	118	132	148	158	40.83%	Vanflyta is an oral medicine used with chemotherapy for adults newly diagnosed with FLT3âITD positive acute myeloid leukemia. It continues working as a maintenance therapy to help keep the cancer in check.
Xdemvy	xdemvy	Lotilaner	lotilaner	25-Jul-23	25-Jul-28	25-Jul-27	TARSUS PHARMACEUTICALS INC	Ophthalmic Drops	0.25%	Antiparasitic	To Treat Demodex Blepharitis	180	337	485	668	789	920	1,049	1,209	44.69%	Xdemvy is an eye drop treatment that targets and kills Demodex mites to treat blepharitis (eyelid inflammation). Apply twice daily for six weeks to clear up symptoms.
Zurzuvae	zurzuvae	Zuranolone	zuranolone	04-Aug-23	04-Aug-28	04-Aug-27	BIOGEN INC	Capsule	20mg, 25mg and 30mg	Antidepressant	To Treat Postpartum Depression	72	232	352	487	600	693	775	838	69.90%	Zurzuvae is a 14-day oral pill for adults with postpartum depression, offering rapid improvement in depressive symptoms. It helps new mothers regain mood balance after childbirth.
Izervay	izervay	Avacincaptad Pegol	avacincaptad-pegol	04-Aug-23	04-Aug-28	04-Aug-27	IVERIC BIO INC	Intravitreal Solution	EQ 2MG BASE/0.1ML	Ophthalmic	To Treat Geographic Atrophy Secondary To Age-Related Macular Degeneration	382	584	812	1,026	1,209	1,418	1,599	1,775	33.38%	Izervay is a monthly injection into the eye to treat geographic atrophy caused by age-related macular degeneration. It slows vision loss by targeting a key protein involved in retinal cell death.
Sohonos	sohonos	Palovarotene	palovarotene	16-Aug-23	16-Aug-28	16-Aug-27	IPSEN BIOPHARMACEUTICALS INC	Oral Capsules	1mg, 1.5mg, 2.5mg, 5mg and 10mg	Antiossification	To Reduce The Volume Of New Heterotopic Ossification In Adults And Pediatric Patients (Aged 8 Years And Older For Females And 10 Years And Older For Males) With Fibrodysplasia Ossificans Progressiva	23	22	25	30	36	38	43	48	11.85%	Sohonos is a daily oral capsule for patients (8 + for females, 10 + for males) with fibrodysplasia ossificans progressiva (FOP), a condition causing abnormal bone growth. It slows new bone formation by activating retinoic acid receptors.
Aphexda	aphexda	Motixafortide	motixafortide	08-Sep-23	09-Aug-28	09-Aug-27	BIOLINERX LTD	Subcutaneous Powder	62MG BASE/VIAL	Stem Cell Mobilizer	To Use With Filgrastim (G-CSF) To Mobilize Hematopoietic Stem Cells To The Peripheral Blood For Collection And Subsequent Autologous Transplantation In Patients With Multiple Myeloma	NA	NA	NA	NA	NA	NA	NA	NA	NA	Aphexda, used together with filgrastim, is a stem cell mobilizer for patients with multiple myeloma undergoing autologous transplant. By blocking CXCR4 receptors, it increases stem cells circulating in the blood for effective collection.
Ojjaara	ojjaara	Momelotinib	momelotinib	15-Sep-23	15-Sep-28	15-Sep-27	GLAXOSMITHKLINE LLC	Tablet	100mg, 150mg and 200mg	Anticancer	To Treat Intermediate Or High-Risk Myelofibrosis In Adults With Anemia	451	804	1,063	1,251	1,430	1,585	1,730	1,718	33.44%	Ojjaara is an oral medication for adults with intermediate or high-risk myelofibrosis and anemia. It targets JAK1, JAK2, and ACVR1 to reduce spleen size, relieve symptoms, and improve anemia.
Exxua	exxua	Gepirone	gepirone	22-Sep-23	22-Sep-28	22-Sep-27	FABRE KRAMER PHARMACEUTICALS INC	Extended Release Tablets	18.2mg, 36.3mg, 54.5mg and 72.6mg	Antidepressant	To Treat Major Depressive Disorder	NA	17	46	88	135	165	NA	NA	NA	Exxua is an extended-release oral antidepressant for adults with major depressive disorder. It selectively activates serotonin 5âHT1A receptors, offering symptom relief with low risk of sexual side effects.
Rivfloza	rivfloza	Nedosiran	nedosiran	29-Sep-23	29-Sep-28	29-Sep-27	NOVO NORDISK INC	Injection	80mg base /0.5ml, 128mg base/ 0.8ml, 160mg base/ 1ml	Antimetabolic Disorder	To Lower Urinary Oxalate Levels In Patients 9 Years And Older With Primary Hyperoxaluria Type 1 And Relatively Preserved Kidney Function	NA	89	141	190	216	233	242	253	NA	Rivfloza is a once-monthly injection for children more than 2 years old and adults with primary hyperoxaluria type 1. It lowers urine oxalate levels by silencing a liver enzyme, helping protect kidney function.
Velsipity	velsipity	Etrasimod	etrasimod	12-Oct-23	12-Oct-28	12-Oct-27	PFIZER INC	Tablet	2mg base	Antiulcer	To Treat Moderately To Severely Active Ulcerative Colitis In Adults	NA	174	331	468	600	736	892	1,018	NA	Velsipity is a once-daily pill for adults with moderately to severely active ulcerative colitis. It modulates S1P receptors to reduce inflammation and maintain remission.
Zilbrysq	zilbrysq	Zilucoplan	zilucoplan	17-Oct-23	17-Oct-28	17-Oct-27	UCB INC	Subcutaneous Injection	16.6MG BASE/0.416ML, 23MG BASE/0.574ML, 32.4MG BASE/0.81ML	Immunomodulators	To Treat Generalized Myasthenia Gravis In Adults Who Are Anti-Acetylcholine Receptor (AChR) Antibody Positive	78	189	315	421	505	571	619	631	59.51%	Zilbrysq is a once-daily self-administered injection for adults with generalized myasthenia gravis who test positive for anti-AChR antibodies. It blocks the complement C5 protein to reduce muscle weakness and improve strength.
Agamree	agamree	Vamorolone	vamorolone	26-Oct-23	26-Oct-28	26-Oct-27	CATALYST PHARMACEUTICALS INC	Oral Suspension	40MG/ML	Neuroprotective	To Treat Duchenne Muscular Dystrophy	46	148	231	296	353	389	419	446	66.44%	Agamree is an oral suspension for Duchenne muscular dystrophy in children aged 2 and older. Itâs a steroid-type medicine that helps protect muscles and slow disease progression.
Fruzaqla	fruzaqla	Fruquintinib	fruquintinib	08-Nov-23	08-Nov-28	08-Nov-27	TAKEDA PHARMACEUTICALS USA INC	Capsule	1mg & 5mg	Anticancer	To Treat Refractory, Metastatic Colorectal Cancer	354	368	426	480	470	467	487	508	7.34%	Fruzaqla is a once-daily oral treatment for metastatic colorectal cancer in adults who have already tried other therapies. It inhibits VEGF receptors to slow tumor growth and improve survival.
Defencath	defencath	Taurolidine And Heparin	taurolidine-and-heparin	15-Nov-23	15-Nov-28	15-Nov-27	CORMEDIX INC	Single Dose Vial To Instill In Central Venous Catheters	3,000 UNITS/3ML (1,000 UNITS/ML);40.5MG/3ML (13.5MG/ML), 5,000 UNITS/5ML (1,000 UNITS/ML);67.5MG/5ML (13.5MG/ML)	Antimicrobial And Anticoagulant	To Reduce The Incidence Of Catheter-Related Bloodstream Infections In Adults With Kidney Failure Receiving Chronic Hemodialysis Through A Central Venous Catheter	NA	165	247	274	333	341	400	457	NA	Defencath is a catheter lock solution used in adult dialysis patients with central venous catheters. It helps prevent bloodstream infections by combining antimicrobial and anti-clotting effects.
Augtyro	augtyro	Repotrectinib	repotrectinib	15-Nov-23	15-Nov-28	15-Nov-27	BRISTOL MYERS SQUIBB CO	Capsule	40mg	Anticancer	To Treat ROS1-Positive Non-Small Cell Lung Cancer	39	107	196	286	367	434	485	526	75.15%	Augtyro is an oral treatment for ROS1-positive non-small cell lung cancer and NTRK fusionâpositive tumors. It blocks key cancer-driving proteins to help slow tumor growth, especially in patients who've tried other therapies.
Truqap	truqap	CapIVasertib	capivasertib	16-Nov-23	16-Nov-28	16-Nov-27	ASTRAZENECA PHARMACEUTICALS LP	Tablet	160mg and 200mg	Anticancer	To Treat Breast Cancer That Meets Certain Disease Criteria	430	633	828	1,049	1,235	1,399	1,572	1,735	30.18%	Truqap is used with fulvestrant to treat certain advanced breast cancers with specific genetic mutations. It works by blocking the AKT pathway, which helps control tumor cell survival and growth.
Ogsiveo	ogsiveo	Nirogacestat	nirogacestat	27-Nov-23	27-Nov-28	27-Nov-27	SPRINGWORKS THERAPEUTICS INC	Tablet	50mg	Anticancer	To Treat Adults With Progressing Desmoid Tumors Who Require Systemic Treatment	172	146	400	533	671	806	974	1,063	40.54%	Ogsiveo is an oral therapy for adults with desmoid tumors that are actively progressing. It targets a protein involved in tumor formation, helping reduce tumor size and manage symptoms.
Fabhalta	fabhalta	Iptacopan	iptacopan	05-Dec-23	05-Dec-28	05-Dec-27	NOVARTIS PHARMACEUTICALS CORP	Capsule	200mg	Immunomodulators	To Treat Paroxysmal Nocturnal Hemoglobinuria	129	487	985	1,493	1,945	2,364	2,765	3,124	97.05%	Fabhalta is an oral capsule that helps treat rare blood and kidney diseases by inhibiting complement factor B. Itâs approved for adults with paroxysmal nocturnal hemoglobinuria (PNH), and to reduce proteinuria in complement 3 glomerulopathy (C3G) and IgA nephropathy.
Filsuvez	filsuvez	Birch Triterpenes	birch-triterpenes	18-Dec-23	18-Dec-28	18-Dec-27	CHIESI FARMACEUTICI SPA	Topical Gel	10%	Dermatologic	To Treat Wounds Associated With Dystrophic And Junctional Epidermolysis Bullosa	NA	NA	NA	NA	NA	NA	NA	NA	NA	Filsuvez is a topical gel used on open wounds in patients with dystrophic or junctional epidermolysis bullosa (EB). Itâs the first treatment that supports skin healing in this condition by promoting wound closure.
Wainua	wainua	Eplontersen	eplontersen	21-Dec-23	21-Dec-28	21-Dec-27	ASTRAZENECA AB	Subcutaneous Injection	45MG BASE/0.8ML	Neuroprotective	To Treat Polyneuropathy Of Hereditary Transthyretin-Mediated Amyloidosis	105	305	535	938	1,358	1,855	2,302	2,746	89.64%	Wainua is a subcutaneous injection designed for adults managing nerve damage caused by hereditary transthyretin-mediated amyloidosis (ATTRvâPN). It works via an antisense therapy that reduces the abnormal protein buildup damaging the nerves.
Zelsuvmi	zelsuvmi	Berdazimer	berdazimer	05-Jan-24	05-Jan-29	05-Jan-28	LNHC INC	Topical Gel	EQ 10.3% BASE	Antiviral	To Treat Molluscum Contagiosum	NA	1	6	13	17	24	29	35	NA	Zelsuvmi is a topical gel applied to molluscum contagiosum skin lesions in patients aged one year and older. The gel releases nitric oxide to clear lesions and is the only at-home prescription treatment for this viral infection.
Exblifep	exblifep	Cefepime And Enmetazobactam	cefepime-and-enmetazobactam	22-Feb-24	22-Feb-29	22-Feb-28	ALLECRA THERAPEUTICS SAS	IV Powder	EQ 2GM BASE-VIAL;0.5GM-VIAL	Antibiotic	To Treat Complicated Urinary Tract Infections	NA	NA	NA	NA	NA	NA	NA	NA	NA	Exblifep is an antibiotic drug used in adults to treat complicated urinary tract infections, such as kidney infections, hospital-acquired pneumonia, including ventilator-associated pneumonia, and bacteraemia when associated or suspected to be associated with these infections.
Rezdiffra	rezdiffra	Resmetirom	resmetirom	14-Mar-24	14-Mar-29	14-Mar-28	MADRIGAL PHARMACEUTICALS INC	Tablet	60mg, 80mg, 100mg	Antimetabolic Disorder	To Treat Noncirrhotic Non-Alcoholic Steatohepatitis With Moderate To Advanced Liver Scarring	180	675	1,126	1,726	2,463	3,405	4,151	4,847	92.33%	Rezdiffra is a prescription medication indicated for the treatment of non-cirrhotic non-alcoholic steatohepatitis (NASH) in individuals with mild to severe hepatic fibrosis. It is used to promote improved liver health in conjunction with a balanced diet and consistent exercise.
Tryvio	tryvio	Aprocitentan	aprocitentan	19-Mar-24	19-Mar-29	19-Mar-28	IDORSIA PHARMACEUTICALS LTD	Tablet	12.5mg	Antihypertensive	To Treat Hypertension	NA	17	31	49	68	83	86	91	NA	Tryvio is an oral tablet that lowers blood pressure in adults whose hypertension isnât managed well despite using multiple medications. It blocks endothelin receptors to relax blood vessels, reducing risks of stroke and heart attack.
Duvyzat	duvyzat	Givinostat	givinostat	21-Mar-24	21-Mar-29	21-Mar-28	ITALFARMACO SPA	Oral Suspension	EQ 8.86MG BASE-ML	Neuromuscular Agents	To Treat Duchenne Muscular Dystrophy In Individuals Aged 6 Years And Older	NA	363	393	432	484	543	600	NA	NA	Duvyzat is an oral histone deacetylase inhibitor prescribed for Duchenne muscular dystrophy in patients aged six and older. It slows muscle degeneration, reduces inflammation, and supports muscle strength by modulating gene regulation processes.
Vafseo	vafseo	Vadadustat	vadadustat	27-Mar-24	27-Mar-29	27-Mar-28	AKEBIA THERAPEUTICS INC	Oral Tablets	150mg, 300mg and 450mg tablet	Antianemic	To Treat Anemia Due To Chronic Kidney Disease	14	102	231	312	408	518	619	730	132.34%	Vafseo is an oral tablet that treats anemia in adults with chronic kidney disease on dialysis by boosting natural erythropoietin production through HIFâprolyl hydroxylase inhibition. It minimizes the need for blood transfusions while carrying a caution for cardiovascular and clotting risks .
Voydeya	voydeya	Danicopan	danicopan	29-Mar-24	29-Mar-29	29-Mar-28	ALEXION PHARMACEUTICALS INC	Oral Tablets	50mg and 100mg	Immunomodulators	To Treat Extravascular Hemolysis With Paroxysmal Nocturnal Hemoglobinuria	NA	77	145	200	253	299	341	381	NA	Voydeya is an oral complement factor D inhibitor added to standard therapy in adults with paroxysmal nocturnal hemoglobinuria. It helps reduce ongoing hemolysis outside blood vessels, improving anemia.
Zevtera	zevtera	Ceftobiprole Medocaril Sodium	ceftobiprole-medocaril-sodium	03-Apr-24	03-Apr-29	03-Apr-28	BASILEA PHARMACEUTICA INTERNATIONAL LTD ALLSCHWIL	Intravenous Powder Injection	667MG-VIAL	Antibiotic	To Treat Certain Bloodstream Infections, Bacterial Skin And Associated Tissue Infections, And Community-Acquired Bacterial Pneumonia	NA	NA	NA	NA	NA	NA	NA	NA	NA	Zevtera is an advanced-generation cephalosporin antibiotic for treating Staphylococcus aureus bacteremia, including right-sided endocarditis, skin infections, and pneumonia in both adults and children. It works by blocking bacterial cell wall synthesis and remains active against MRSA and resistant strains.
Lumisight	lumisight	Pegulicianine	pegulicianine	17-Apr-24	17-Apr-29	17-Apr-28	LUMICELL INC	Intravenous Powder Injection	EQ 40MG BASE-VIAL	Diagnostic Agents	To Use As An Optical Imaging Agent For The Detection Of Cancerous Tissue	NA	NA	NA	NA	NA	NA	NA	NA	NA	Lumisight is an IV fluorescent imaging agent used during lumpectomy to highlight residual breast cancer tissue inside the surgical cavity. This real-time tool helps surgeons ensure more complete tumor removal and aims to lower the need for additional surgery.
Ojemda	ojemda	Tovorafenib	tovorafenib	23-Apr-24	23-Apr-29	23-Apr-28	DAY ONE BIOPHARMACEUTICALS INC	Oral Suspension	25MG-ML	Anticancer	To Treat Relapsed Or Refractory Pediatric Low-Grade Glioma	57	156	255	363	497	641	779	924	71.84%	Ojemda is the first FDA-approved targeted therapy for children 6 months and older with relapsed or treatment-resistant pediatric low-grade glioma (pLGG) caused by certain BRAF gene changes.
Xolremdi	xolremdi	Mavorixafor	mavorixafor	26-Apr-24	26-Apr-29	26-Apr-28	X4 PHARMACEUTICALS INC	Oral Capsules	100MG	Immunomodulators	To Treat WHIM Syndrome (Warts, Hypogammaglobulinemia, Infections And Myelokathexis)	3	26	59	107	188	378	578	763	181.36%	Xolremdi is a once-daily pill that helps people aged 12 years and older with WHIM syndrome by increasing important white blood cells to strengthen the bodyâs defense against infections.
Rytelo	rytelo	Imetelstat	imetelstat	06-Jun-24	06-Jun-29	06-Jun-28	GERON CORP	Intravenous Powder	EQ 47MG BASE-VIAL & EQ 188MG BASE-VIAL	Anticancer	To Treat Low- To Intermediate-1 Risk Myelodysplastic Syndromes	77	269	484	734	1,067	1,371	1,704	2,028	92.94%	Rytelo is a prescription treatment for adults with low-to-intermediate-1 risk myelodysplastic syndromes (MDS) who have anemia and need frequent blood transfusions, and who haven't responded to or can't take erythropoiesis-stimulating agents (ESAs).
Iqirvo	iqirvo	Elafibranor	elafibranor	10-Jun-24	10-Jun-29	10-Jun-28	IPSEN BIOPHARMACEUTICALS INC	Oral Tablets	80MG	Hepatoprotective Agents	To Treat Primary Biliary Cholangitis In Combination With Ursodeoxycholic Acid	24	137	242	353	436	515	593	649	106.45%	Iqirvo is used with ursodeoxycholic acid to treat primary biliary cholangitis. It works by targeting key pathways in the liver, including PPAR alpha and PPAR delta.
Sofdra	sofdra	Sofpironium	sofpironium	18-Jun-24	18-Jun-29	18-Jun-28	BOTANIX SB INC	Metered Gel Topical	EQ 12.45% BASE (EQ 72MG BASE-ACTUATION)	Antiperspirant	To Treat Primary Axillary Hyperhidrosis	NA	NA	NA	NA	NA	NA	NA	NA	NA	Sofdra is a topical anticholinergic gel for adults and children aged 9 and up suffering from underarm excessive sweating (primary axillary hyperhidrosis). Applied at bedtime, it helps reduce sweat production by blocking signals to sweat glands
Ohtuvayre	ohtuvayre	Ensifentrine	ensifentrine	26-Jun-24	26-Jun-29	26-Jun-28	VERONA PHARMA INC	Suspension; Inhalation	3MG-2.5ML	Respiratory Agents	To Treat Chronic Obstructive Pulmonary Disease	42	249	540	745	984	1,294	1,677	2,110	120.01%	Ohtuvayre is an inhaled medication for adults with moderate to severe COPD, offering a new option beyond traditional steroids and bronchodilators. It targets two enzymes (PDE3 and PDE4) to both open airways and reduce lung inflammation
Leqselvi	leqselvi	Deuruxolitinib	deuruxolitinib	25-Jul-24	25-Jul-29	25-Jul-28	SUN PHARMACEUTICAL INDUSTRIES INC	Oral Tablets	8 mg	Immunomodulators	To Treat Severe Alopecia Areata	7	58	125	175	231	287	342	397	139.68%	Leqselvi is an oral tablet prescribed for adults with severe alopecia areata, a condition that causes widespread hair loss. It works by blocking specific Janus kinase enzymes involved in the autoimmune process, leading to significant hair regrowth over 30% of patients saw at least 80% scalp coverage in clinical trials
Yorvipath	yorvipath	Palopegteriparatide	palopegteriparatide	09-Aug-24	09-Aug-29	09-Aug-28	ASCENDIS PHARMA BONE DISEASES AS	Subcutaneous Solutions	EQ 0.168MG , EQ 0.294MG & EQ 0.42MG	Hormonal Therapy	To Treat Hypoparathyroidism	31	372	745	1,159	1,554	1,872	2,118	2,413	166.09%	Yorvipath is used to treat hypoparathyroidism. It is a ready-to-use injection that is administered once aÂ day to people with hypoparathyroidism.
Voranigo	voranigo	Vorasidenib	vorasidenib	06-Aug-24	06-Aug-29	06-Aug-28	SERVIER PHARMACEUTICALS LLC	Oral Tablets	10 mg and 40 mg	Anticancer	To Treat Grade 2 Astrocytoma Or Oligodendroglioma	NA	102	134	156	167	173	177	183	NA	Voranigo is an oral treatment for adults and teens with Grade 2 astrocytoma or oligodendroglioma that carry an IDH1 or IDH2 mutation, used after surgery. It blocks mutant IDH enzymes to slow tumor progression, significantly extending the time before disease worsens
Livdelzi	livdelzi	Seladelpar	seladelpar	14-Aug-24	14-Aug-29	14-Aug-28	GILEAD SCIENCES INC	Capsule	10mg	Hepatoprotective Agents	To Treat Primary Biliary Cholangitis (PBC)	NA	241	597	942	1,317	1,638	1,888	1,784	NA	Livdelzi is used to treat primary biliary cholangitis (PBC). The purpose of Livdelzi is to efficiently target PPARÎ´, a peroxisome proliferator-activated receptor delta that inhibits the formation of bile acids.
Lazcluze	lazcluze	Lazertinib	lazertinib	19-Aug-24	19-Aug-29	19-Aug-28	JANSSEN BIOTECH INC	Oral Tablets	80mg and 240mg	Anticancer	To Treat Non-Small Cell Lung Cancer	327	653	1,861	3,462	4,442	5,444	6,719	7,731	91.98%	Lazcluze (lazertinib) is an oral targeted therapy used with amivantamab for adults with advanced EGFR-mutated nonâsmall cell lung cancer. This regimen blocks mutant EGFR to delay disease progression, extending median progression-free survival to about 23.7 months.
Miplyffa	miplyffa	Arimoclomol	arimoclomol	20-Sep-24	20-Sep-29	20-Sep-28	ZEVRA DENMARK AS	Oral Capsules	47mg, 62mg, 93mg and 124mg	Neuroprotective	To Treat Niemann-Pick Disease Type C	10	77	144	191	225	248	267	285	117.79%	Miplyffa is used to treat Niemann-Pick disease type C. The combination of the drug Miplyffa and miglustat is suggested for the treatment of neurological symptoms of Niemann-Pick disease type C in adults as well as children who are at least two years old.
Aqneursa	aqneursa	Levacetylleucine	levacetylleucine	24-Sep-24	24-Sep-29	24-Sep-28	INTRABIO INC	Oral Suspension	1gm-packet	Neuroprotective	To Treat Niemann-Pick Disease Type C	NA	NA	NA	NA	NA	NA	NA	NA	NA	Aqneursa is an oral granule formulation for patients aged 4 years and older with NiemannâPick disease type C. It improves neurological symptoms like coordination and balance by enhancing mitochondrial and lysosomal function and reducing cholesterol buildup in nerve cells.
Cobenfy	cobenfy	Xanomeline And Trospium Chloride	xanomeline-and-trospium-chloride	26-Sep-24	26-Sep-29	26-Sep-28	BRISTOL-MYERS SQUIBB CO	Oral Capsules	50mg, 100mg and 125mg	Antipsychotic	To Treat Schizophrenia	10	166	493	1,009	1,732	2,525	3,194	3,836	262.77%	Cobenfy is used to treat schizophrenia. It is the first and only FDA-approved medication for schizophrenia. This drug worksÂ by activating muscarinic acetylcholine receptors, which are small proteins in the brain.
Flyrcado	flyrcado	Flurpiridaz F 18	flurpiridaz-f-18	27-Sep-24	27-Sep-29	27-Sep-28	GE HEALTHCARE INC	Intravenous Injection	5-55mCi-ML	Diagnostic Agents	A Radioactive Diagnostic Drug To Evaluate For Myocardial Ischemia And Infarction	NA	NA	NA	NA	NA	NA	NA	NA	NA	Flyrcado is an IV PET imaging agent for adults with known or suspected coronary artery disease. It highlights blood flow to the heart under rest or stress, helping doctors accurately detect ischemia or areas at risk of infarction.
Itovebi	itovebi	Inavolisib	inavolisib	10-Oct-24	10-Oct-29	10-Oct-28	GENENTECH INC	Oral Tablets	3mg and 9mg	Anticancer	To Treat Locally Advanced Or Metastatic Breast Cancer	9	157	396	692	990	1,321	1,626	1,908	223.85%	Itovebi is an oral targeted therapy, added to palbociclib and fulvestrant, for HR-positive, HER2-negative advanced breast cancer with PIK3CA mutations. It inhibits mutant PI3KÎ± to slow tumor progression and extend progression-free survival.
Orlynvah	orlynvah	Sulopenem Etzadroxil And Probenecid	sulopenem-etzadroxil-and-probenecid	25-Oct-24	25-Oct-29	25-Oct-28	ITERUM THERAPEUTICS US LTD	Oral Tablets	500mg; 500mg	Antibiotic	To Treat Uncomplicated Urinary Tract Infections (uUTI)	NA	1	4	12	30	61	93	117	NA	Orlynvah is an oral tablet for adult women with uncomplicated urinary tract infections caused by E. coli, K. pneumoniae, or P. mirabilis, especially for those with limited or no alternative oral antibiotic options. It combines sulopenem (an antibiotic) with probenecid, which helps increase sulopenem levels, delivering strong antibacterial activity comparable or superior to ciprofloxacin and amoxicillin/clavulanate in clinical trials.
Revuforj	revuforj	Revumenib Citrate	revumenib-citrate	15-Nov-24	15-Nov-29	15-Nov-28	SYNDAX PHARMACEUTICALS INC	Oral Tablets	25mg, 110mg and 160mg	Anticancer	To Treat Relapsed Or Refractory Acute Leukemia	8	100	203	323	460	584	712	849	175.37%	Revuforj is a drug used to treat relapsed or refractory acute leukemia. The treatment of acute leukemia is done with a lysine methyltransferase 2A gene translocation (KMT2A) in adults. This drug is also indicated for children 1 year and older whose disease has come back or has not improved after previous treatments.
Attruby	attruby	Acoramidis	acoramidis	22-Nov-24	22-Nov-29	22-Nov-28	BRIDGEBIO PHARMA INC	Oral Tablets	356 mg	Cardiovascular Agents	To Treat Cardiomyopathy Of Wild-Type Or Variant Transthyretin-Mediated Amyloidosis	NA	327	712	1,120	1,513	1,727	2,030	2,315	NA	Attruby is an oral tablet for adults with transthyretin amyloid cardiomyopathy (wild-type or hereditary). It stabilizes misfolded transthyretin proteins, reducing the risk of heart-related death and hospitalization.
Rapiblyk	rapiblyk	Landiolol	landiolol	22-Nov-24	22-Nov-29	22-Nov-28	AOP ORPHAN PHARMACEUTICALS AG	Intravenous Powder Injection	280MG BASE-VIAL	Cardiovascular Agents	To Treat Supraventricular Tachycardia	NA	NA	NA	NA	NA	NA	NA	NA	NA	Rapiblyk is an IV beta-blocker used in hospitals to quickly control heart rate during acute supraventricular tachycardia (like atrial fibrillation or flutter). Its ultra-rapid action slows the heart without significantly lowering blood pressure.
Iomervu	iomervu	Iomeprol	iomeprol	27-Nov-24	27-Nov-29	27-Nov-28	BRACCO DIAGNOSTICS INC	Intra-Arterial And Intravenous	15gm/50ml, 17.5gm/50ml, 20gm/50ml, 25gm/100ml, 30gm/100ml, 35gm/100ml, 40gm/100ml, 60gm/150ml and 45gm/150ml	Diagnostic Agents	For Use As A Radiographic Contrast Agent	NA	NA	NA	NA	NA	NA	NA	NA	NA	Iomervu is an injectable contrast agent for CT scans and angiography in adults and children. It enhances artery and organ imaging by providing clear, safe visualization of vascular structures.
Crenessity	crenessity	Crinecerfont	crinecerfont	13-Dec-24	13-Dec-29	13-Dec-28	NEUROCRINE BIOSCIENCES INC	Oral Capsules	25mg, 50mg and 100mg	Hormonal Therapy	To Treat Classic Congenital Adrenal Hyperplasia	NA	101	266	468	663	854	1037	1,204	NA	Crenessity is used to treat classic congenital adrenal hyperplasia. It is administered together with glucocorticoids to control androgen levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia.
Ensacove	ensacove	Ensartinib	ensartinib	18-Dec-24	18-Dec-29	18-Dec-28	XCOVERY HOLDINGS INC	Oral Capsules	25mg and 100mg	Anticancer	To Treat Non-Small Cell Lung Cancer	NA	NA	NA	NA	NA	NA	NA	NA	NA	Ensacove is an oral kinase inhibitor for adults with ALK-positive, locally advanced or metastatic non-small cell lung cancer who havenât previously received ALK-targeted therapy. It blocks ALK-driven signaling to help control tumor growth and delay disease progression.
Tryngolza	tryngolza	Olezarsen	olezarsen	19-Dec-24	19-Dec-29	19-Dec-28	IONIS PHARMACEUTICALS INC	Subcutaneous Solution	EQ 80MG BASE/0.8ML	Antihyperlipidemic	To Treat Familial Chylomicronemia Syndrome	NA	40	98	175	308	474	632	783	NA	Tryngolza is a subcutaneous injection for adults with familial chylomicronemia syndrome. It reduces APOC-III protein levels to lower dangerously high triglycerides and prevent pancreatitis.
Alyftrek	alyftrek	Vanzacaftor, Tezacaftor, And DeutIVacaftor	vanzacaftor-tezacaftor-and-deutivacaftor	20-Dec-24	20-Dec-29	20-Dec-28	VERTEX PHARMACEUTICALS INC	Oral Tablet	50MG; 20MG; EQ 4MG BASE and 125MG; 50MG; EQ 10MG BASE	Respiratory Agents	To Treat Cystic Fibrosis	NA	720	1,754	2,556	3,425	4,206	4,914	5,604	NA	Alyftrek is a daily oral treatment for cystic fibrosis in patients aged 6 and older with the F508del mutation or other responsive CFTR variants. It helps restore CFTR protein function to improve lung performance and reduce disease flare-ups.
Grafapex	grafapex	Treosulfan	treosulfan	21-Jan-25	21-Jan-30	21-Jan-29	MEDEXUS PHARMA INC	Intravenous Powder	1GM/VIAL and 5GM/VIAL	Anticancer	For Use In Combination With Fludarabine As A Preparative Regimen For Allogeneic Hematopoietic Stem Cell Transplantation For Acute Myeloid Leukemia And Myelodysplastic Syndrome	NA	NA	NA	NA	NA	NA	NA	NA	NA	Grafapex is used with fludarabine to prepare adults and children (â¥1 year) with AML or MDS for stem cell transplant. It helps replace traditional regimens, offering similar effectiveness with potentially fewer side effects
Journavx	journavx	Suzetrigine	suzetrigine	30-Jan-25	30-Jan-30	30-Jan-29	VERTEX PHARMACEUTICALS INC	Oral Tablet	50MG	Anticoagulant	To Treat Moderate To Severe Acute Pain	NA	78	291	628	1,082	1,587	2,133	2,585	NA	Journavx is a nonâopioid oral painkiller approved for adults with moderateâtoâsevere acute pain. It blocks sodiumâchannel pain signals in the body, relieving pain without addiction risk.
Gomekli	gomekli	Mirdametinib	mirdametinib	11-Feb-25	11-Feb-30	11-Feb-29	SPRINGWORKS THERAPEUTICS INC	Oral Capsule And Oral Tablet, For Suspension	1MG and 2MG	Anticancer	To Treat Neurofibromatosis Type 1 Who Have Symptomatic Plexiform Neurofibromas Not Amenable To Complete Resection	NA	41	142	319	512	699	845	969	NA	Gomekli treats adults and children (â¥2 years) with NF1-related plexiform neurofibromas that can't be fully removed. It inhibits MEK enzymes to slow tumor growth and reduce tumor size.
Romvimza	romvimza	Vimseltinib	vimseltinib	14-Feb-25	14-Feb-30	14-Feb-29	DECIPHERA PHARMACEUTICALS LLC	Oral Capsule	14MG, 20MG and 30MG	Anticancer	To Treat Symptomatic Tenosynovial Giant Cell Tumor For Which Surgical Resection Will Potentially Cause Worsening Functional Limitation Or Severe Morbidity	NA	38	73	105	134	160	185	209	NA	Romvimza is a tablet for adults with tenosynovial giant cell tumor when surgery might worsen joint function. It blocks CSF-1R to shrink tumors and ease symptoms.
Blujepa	blujepa	Gepotidacin	gepotidacin	25-Mar-25	25-Mar-30	25-Mar-29	GLAXOSMITHKLINE LLC	Oral Tablet	EQ 750MG BASE	Antibiotic	To Treat Uncomplicated Urinary Tract Infections	NA	52	167	253	345	427	497	567	NA	Blujepa treats uncomplicated urinary tract infections in females and adolescents with more than 12 years and more than or equal to 40 kg. Itâs an oral antibiotic in a new class that combats common UTI bacteria and tackles antibiotic resistance.
Qfitlia	qfitlia	Fitusiran	fitusiran	28-Mar-25	28-Mar-30	28-Mar-29	GENZYME CORP	Subcutaneous Solution	EQ 20MG BASE/0.2ML and EQ 50MG BASE/0.5ML	Hemostatic Agents	To Prevent Or Reduce The Frequency Of Bleeding Episodes In Hemophilia A Or B	NA	54	189	329	448	532	595	660	NA	Qfitlia is a subcutaneous therapy approved for routine prevention of bleeding in patients aged 12 and older with hemophilia A or B, with or without inhibitors. It lowers antithrombin to rebalance clotting and has been shown to reduce annual bleeding rates by around 90%
Vanrafia	vanrafia	Atrasentan	atrasentan	02-Apr-25	02-Apr-30	02-Apr-29	NOVARTIS PHARMACEUTICALS CORP	Oral Tablet	EQ 0.75MG BASE	Nephroprotective	To Reduce Proteinuria In Adults With Primary Immunoglobulin A Nephropathy At Risk Of Rapid Disease Progression	NA	35	136	254	396	527	656	781	NA	Vanrafia is an oral treatment for adults with primary IgA nephropathy at risk of rapid disease progression. It reduces proteinuria and helps protect kidney function by blocking endothelin A receptors.
Avmapki Fakzynja Co-Pack	avmapki-fakzynja-co-pack	Avutometinib And Defactinib	avutometinib-and-defactinib	08-May-25	08-May-30	08-May-29	VERASTEM INC	Oral Capsule And Tablet	EQ 0.8MG BASE; EQ 200MG BASE	Anticancer	To Treat KRAS-Mutated Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) After Prior Systemic Therapy	NA	31	92	150	268	405	540	676	NA	Avmapki Fakzynja combines two oral kinase inhibitors for adults with KRASâmutated recurrent lowâgrade serous ovarian cancer after prior systemic therapy. It targets both MEK and FAK pathways to help control tumor growth in patients with limited treatment options.
Tryptyr	tryptyr	Acoltremon	acoltremon	28-May-25	28-May-30	28-May-29	ALCON LABORATORIES, INC	Ophthalmic Solution/Drops	0.003%	Ophthalmic	To Treat The Signs And Symptoms Of Dry Eye Disease	NA	73	126	218	370	NA	NA	NA	NA	Tryptyr is an oral neuroactive steroid modulator designed to treat dry eye disease. It acts on nervous system pathways to relieve symptoms and improve eye comfort.
Ibtrozi	ibtrozi	Taletrectinib	taletrectinib	11-Jun-25	11-Jun-30	11-Jun-29	NUVATION BIO INC	Oral Capsule	EQ 200MG BASE	Anticancer	To Treat Locally Advanced Or Metastatic ROS1-Positive Non-Small Cell Lung Cancer	NA	9	56	126	207	298	386	471	NA	Ibtrozi is a targeted oral therapy for adults with locally advanced or metastatic ROS1-positive non-small cell lung cancer. This selective ROS1 tyrosine kinase inhibitor received FDA approval in June 2025 with breakthrough therapy designation. Features enhanced CNS penetration for improved efficacy against brain metastases compared to earlier ROS1 inhibitors.
Zegfrovy	zegfrovy	Sunvozertinib	sunvozertinib	02-Jul-25	02-Jul-30	02-Jul-29	DIZAL (JIANGSU) PHARMACEUTICAL CO LTD	Oral Tablet	150MG and 200MG	Anticancer	To Treat Locally Advanced Or Metastatic Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Exon 20 Insertion Mutations, As Detected By An FDA-Approved Test, With Disease Progression On Or After Platinum-Based Chemotherapy	NA	18	45	118	197	279	331	356	NA	Zegfrovy is a significant breakthrough in precision oncology for patients with non-small cell lung cancer (NSCLC) who have EGFR exon 20 insertion mutations. It sets a new benchmark for patients with few therapy alternatives by combining clinically significant efficacy, oral convenience, and highly selective EGFR inhibition. Its quick approval highlights the critical need for efficient treatments in this patient group, and further research attempts to increase its therapeutic benefit in first-line and combo treatment settings.
Ekterly	ekterly	Sebetralstat	sebetralstat	03-Jul-25	03-Jul-30	03-Jul-29	KALVISTA PHARMACEUTICALS LTD	Oral Tablet	300MG	Hereditary Angioedema Agents	To Treat Acute Attacks Of Hereditary Angioedema	NA	7	72	174	286	395	496	590	NA	Ekterly is the first and only oral, on-demand therapy for hereditary angioedema (HAE) attacks in patients aged 12 and older. It works by inhibiting plasma kallikrein, preventing excessive bradykinin production to reduce swelling rapidly. Approved in the U.S. and U.K. in 2025, Ekterly offers fast relief, convenient oral dosing, and a major advance over injectable treatments, giving patients greater independence and control during acute HAE episodes.
Anzupgo	anzupgo	Delgocitinib	delgocitinib	23-Jul-25	23-Jul-30	23-Jul-29	LEO PHARMA AS	Topical Cream	20MG	Dermatologic	To Treat Moderate-To-Severe Chronic Hand Eczema When Topical Corticosteroids Are Not Advisable Or Produce An Inadequate Response	NA	NA	NA	NA	NA	NA	NA	NA	NA	Anzupgo cream is the first and only topical pan-JAK inhibitor approved for adults with moderate to severe chronic hand eczema. By targeting the JAK-STAT pathway, it provides effective, steroid-free relief from inflammation, itching, and skin damage, giving patients a safer and more convenient alternative to traditional treatments.
Sephience	sephience	Sepiapterin	sepiapterin	28-Jul-25	28-Jul-30	28-Jul-29	PTC THERAPEUTICS INC	Oral Powder	250MG/PACKET and 1GM/PACKET	Antimetabolic Disorder	To Treat Hyperphenylalaninemia In Patients With Sepiapterin-Responsive Phenylketonuria, In Conjunction With A Phenylalanine-Restricted Diet	NA	21	115	213	317	405	488	516	NA	Sephience is the first and only oral phenylalanine hydroxylase activator approved for the treatment of hyperphenylalaninemia in adults and children with sepiapterin-responsive phenylketonuria. By delivering sepiapterin, which converts into tetrahydrobiopterin and also prevents PAH misfolding, it enhances enzyme function to reduce blood phenylalanine levels, offering patients a steroid-free, non-invasive, and more convenient alternative to dietary restriction alone.
Vizz	vizz	Aceclidine	aceclidine	31-Jul-25	31-Jul-30	31-Jul-29	LENZ THERAPEUTICS INC	Ophthalmic Solution/Drops	EQ 1.44% BASE	Antiglaucoma Agents	To Treat Presbyopia	NA	4	56	148	213	284	357	428	NA	Vizz is the first and only aceclidine-based eye drop approved for adults with presbyopia. Presbyopia is an age-related blurry near vision. By selectively contracting the iris sphincter muscle to create a pinhole effect and achieve a sub-2 mm pupilâwithout significant ciliary muscle stimulationâit extends depth of focus to provide fast, steroid-free relief of near-vision blur that lasts up to 10 hours. It offers a safe, once-daily, non-surgical alternative to traditional reading glasses and contact lenses.
Modeyso	modeyso	Dordaviprone	dordaviprone	06-Aug-25	06-Aug-30	06-Aug-29	CHIMERIX INC	Oral Capsule	EQ 125MG BASE	Anticancer	To Treat Diffuse Midline Glioma Harboring An H3 K27M Mutation With Progressive Disease Following Prior Therapy	NA	3	47	107	180	235	298	364	NA	Modeyso is an oral protease activator approved for adults and children with recurrent H3 K27M-mutant diffuse midline glioma (DMG), a rare and aggressive brain tumor. By activating mitochondrial caseinolytic protease P (ClpP) and antagonizing dopamine D2 receptors, it induces stress-response pathways, apoptosis, and restoration of histone H3 trimethylation, ultimately slowing tumor growth. Taken once weekly on an empty stomach, Modeyso provides a systemic, non-invasive treatment option in an area where effective therapies have historically been limited.
Hernexeos	hernexeos	Zongertinib	zongertinib	08-Aug-25	08-Aug-30	08-Aug-29	BOEHRINGER INGELHEIM PHARMACEUTICALS INC	Oral Tablet	60MG	Anticancer	To Treat Adults With Unresectable Or Metastatic Non-Squamous Non-Small Cell Lung Cancer Whose Tumors Have HER2 Tyrosine Kinase Domain Activating Mutations, As Detected By An FDA-Approved Test, And Who Have Received Prior Systemic Therapy	NA	NA	5	11	24	38	47	52	NA	Hernexeos is an oral tyrosine kinase inhibitor used to treat adult patients with unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors harbor HER2 (ERBB2) tyrosine kinase domain (TKD) activating mutations. Treatment is indicated following prior systemic therapy, and eligibility requires confirmation of the HER2 mutation via an FDA-approved test.
Brinsupri	brinsupri	Brensocatib	brensocatib	12-Aug-25	12-Aug-30	12-Aug-29	INSMED INC	Oral Tablet	10MG and 25MG	Respiratory Agents	To Treat Non-Cystic Fibrosis Bronchiectasis	NA	42	489	996	1,629	2,425	3,179	3,884	NA	Brinsupri is an oral, once-daily dipeptidyl peptidase-1 (DPP1) inhibitor for the treatment of non-cystic fibrosis bronchiectasis (NCFB) in adults and adolescents aged 12 years and older. It represents the first FDA-approved targeted therapy for this chronic, progressive lung disease, directly addressing neutrophil-driven inflammation rather than just symptom management.
Dawnzera	dawnzera	Donidalorsen	donidalorsen	21-Aug-25	21-Aug-30	21-Aug-29	IONIS PHARMACEUTICALS, INC	Injection	80MG	Hereditary Angioedema Agents	To Prevent Attacks Of Hereditary Angioedema	NA	15	77	168	261	331	401	470	NA	Dawnzera is an RNA-targeted antisense oligonucleotide indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in patients aged 12 years and older. It works by selectively reducing prekallikrein production, thereby lowering bradykinin formation, to significantly reduce the frequency and severity of swelling episodes. The drug is administered via a subcutaneous autoinjector every 4 weeks, offering a convenient self-injectable prophylactic option for this serious condition.
Wayrilz	wayrilz	Rilzabrutinib	rilzabrutinib	29-Aug-25	29-Aug-30	29-Aug-29	GENZYME CORP	Oral Tablet	400MG	Immunomodulators	To Treat Persistent Or Chronic Immune Thrombocytopenia That Has Not Sufficiently Responded To Immunoglobulins, Anti-D Therapy, Or Corticosteroids	NA	23	133	223	345	445	562	677	NA	Wayrilz is an oral reversible BTK inhibitor indicated for adults with chronic immune thrombocytopenia (ITP). It works by modulating immune pathways to increase platelet counts and reduce the risk of bleeding, offering a convenient twice-daily oral treatment option.
Forzinity	forzinity	Elamipretide	elamipretide	19-Sep-25	19-Sep-30	19-Sep-29	STEALTH BIOTHERAPEUTICS INC	Subcutaneous Solution	EQ 280MG BASE/3.5ML (EQ 80MG BASE/ML)	Mitochondrial Dysfunction Agent	To Improve Muscle Strength In Patients With Barth Syndrome Weighing At Least 30 Kg	NA	NA	NA	NA	NA	NA	NA	NA	NA	Forzinity is a mitochondrial-targeted therapy for Barth syndrome in patients weighing 30 kg or more. It stabilizes mitochondrial function to improve energy production and muscle strength, administered via subcutaneous injection.
Inluriyo	inluriyo	Imlunestrant	imlunestrant	25-Sep-25	25-Sep-30	25-Sep-29	ELI LILLY AND COMPANY	Oral Tablet	200MG	Anticancer	To Treat Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative, Estrogen Receptor-1-Mutated Advanced Or Metastatic Breast Cancer With Disease Progression Following At Least One Line Of Endocrine Therapy	NA	9	143	236	341	445	539	630	NA	Inluriyo is an oral selective estrogen receptor degrader (SERD) indicated for ER-positive, HER2-negative, ESR1-mutated advanced breast cancer. It degrades estrogen receptors to block tumor growth, offering a convenient daily oral option.
Palsonify	palsonify	Paltusotine	paltusotine	25-Sep-25	25-Sep-30	25-Sep-29	CRINETICS PHARMA INC	Oral Tablet	20MG and 30MG	Hormonal Therapy	To Treat Acromegaly In Adults Who Had An Inadequate Response To Surgery And/Or For Whom Surgery Is Not An Option	NA	5	52	121	213	346	469	621	NA	Palsonify is an oral somatostatin receptor agonist approved for adults with acromegaly. It suppresses excess growth hormone and IGF-1 levels, providing a once-daily, non-injectable alternative to traditional therapies.
Rhapsido	rhapsido	Remibrutinib	remibrutinib	30-Sep-25	30-Sep-30	30-Sep-29	NOVARTIS PHARMS CORP	Oral Tablet	25MG	Immunomodulators	To Treat Chronic Spontaneous Urticaria In Adults Who Remain Symptomatic Despite H1 Antihistamine Treatment	NA	29	238	554	934	1,293	1,636	1,931	NA	Rhapsido is an oral BTK inhibitor indicated for chronic spontaneous urticaria (CSU). By blocking mast cell activation and histamine release, it effectively reduces hives and itch in patients unresponsive to antihistamines.

Brand Name	Brand Name Slug	Molecule	Molecule Slug	Approval Date	Market Exclusivity Expiry	Data Exclusivity Expiry	Innovator	Dosage Form	Strength	Therapeutic Category	Usage	Revenue ($M)	Projected Sales By 2025 ($M)	Projected Sales By 2026 ($M)	Projected Sales By 2027 ($M)	Projected Sales By 2028 ($M)	Projected Sales By 2029 ($M)	Projected Sales By 2030 ($M)	Projected Sales By 2031 ($M)	CAGR (%)	Description	Question 1	Answer 1	Question 2	Answer 2	Question 3	Answer 3	Question 4	Answer 4
Leqembi	leqembi	Lecanemab-Irmb	lecanemab-irmb	06-Jan-23	06-Jan-35	06-Jan-27	EISAI INC.	Injection	500 mg/5 mL (100 mg/mL), 200 mg/2 mL (100 mg/mL)	Antialzheimer	To Treat Alzheimerâs Disease	312	768	1,282	1,988	2,788	3,597	4,338	4,993	72.90%	Leqembi is a prescription medicine for early-stage Alzheimerâs disease. Itâs a monoclonal antibody that helps reduce amyloid plaques in the brain and is the first treatment of its kind approved in the European Union.	What is Leqembi and how does it work?	Leqembi is a monoclonal antibody treatment for early-stage Alzheimer's disease. It works by targeting and reducing amyloid plaques in the brain, potentially helping to slow cognitive decline in patients with mild cognitive impairment or mild dementia.	Who is eligible for Leqembi treatment?	Leqembi is for patients with early-stage Alzheimer's disease, specifically mild cognitive impairment or mild dementia. Patients must have confirmed elevated beta-amyloid in the brain through testing like PET scans or spinal fluid analysis.	How is Leqembi administered?	Leqembi is given as an IV infusion every two weeks at a healthcare facility. Each session requires medical supervision and regular monitoring by healthcare professionals.	What are the potential side effects and monitoring requirements?	The most common side effects of LEQEMBI include infusion-related reactions, ARIA, and headaches.
Lamzede	lamzede	Velmanase Alfa-Tycv	velmanase-alfa-tycv	16-Feb-23	16-Feb-35	16-Feb-27	CHIESI FARMACEUTICI S.P.A.	Injection- IV	10 mg	Antimetabolic Disorder	To Treatment Of Non-Central Nervous System Manifestations Of Alpha-Mannosidosis In Adult And Pediatric Patients.	NA	NA	NA	NA	NA	NA	NA	NA	NA	Lamzede is the first enzyme replacement therapy for non-central nervous system manifestations of alpha-mannosidosis. It improves enzyme activity and reduces the buildup of serum oligosaccharides.
Zynyz	zynyz	Retifanlimab-Dlwr	retifanlimab-dlwr	22-Mar-23	22-Mar-35	22-Mar-27	INCYTE	Intravenous Injection	500mg/20ml	Anticancer	It Is Indicated For The Treatment Of Adult Patients With Metastatic Or Recurrent Locally Advanced Merkel Cell Carcinoma (MCC).	3	19	55	99	134	166	198	223	158.52%	Zynyz is the first PDâ1 inhibitor approved by the FDA for adult patients with inoperable locally recurrent or metastatic squamous cell carcinoma of the anal canal. It is now available both as monotherapy and in combination with platinumâbased chemotherapy, and is also approved for metastatic Merkel cell carcinoma; it enhances Tâcell activity to target and slow tumor growth.
Elfabrio	elfabrio	Pegunigalsidase Alfa-Iwxj	pegunigalsidase-alfa-iwxj	09-May-23	09-May-35	09-May-27	PROTALIX BIOTHERAPEUTICS, INC.	Injection	20mg/10ml	Antimetabolic Disorder	To Treat Confirmed Fabry Disease	NA	29	NA	NA	NA	NA	50	NA	NA	Elfabrio is the first PEGylated enzyme replacement therapy approved by the FDA for adults with Fabry disease. It provides exogenous alphaâgalactosidase A to reduce globotriaosylceramide accumulation and improve organ function.
Epkinly	epkinly	Epcoritamab-Bysp	epcoritamab-bysp	19-May-23	19-May-35	19-May-27	GENMAB AND ABBVIE	Injection	4 mg/0.8 mL and 48 mg/0.8 mL	Anticancer	To Treat Relapsed Or Refractory Diffuse Large B-Cell Lymphoma (Not Otherwise Specified) And High-Grade B-Cell Lymphoma After Two Or More Lines Of Systemic Therapy	399	734	1,236	1,971	2,608	3,190	3,668	4,080	59.89%	Epkinly is an injection used for certain types of blood cancer like large B-cell lymphoma. It helps immune cells find and destroy cancer cells.
Columvi	columvi	Glofitamab-Gxbm	glofitamab-gxbm	15-Jun-23	15-Jun-35	15-Jun-27	ROCHE	IV Injection	2.5mg/2.5ml and 10mg/10ml	Anticancer	To Treat Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, Or Large B-Cell Lymphoma Arising From Follicular Lymphoma After Two Or More Lines Of Systemic Therapy	195	387	624	890	1,163	1,394	1,618	1,840	56.27%	Columvi is an antibody-based therapy for adults with relapsed or refractory diffuse large B-cell lymphoma. It activates the immune system to target and destroy cancer cells when other treatments have failed.
Rystiggo	rystiggo	Rozanolixizumab-Noli	rozanolixizumab-noli	26-Jun-23	26-Jun-35	26-Jun-27	UCB	Subcutaneous Injection	280mg/2ml	Immunomodulators	To Treat Generalized Myasthenia Gravis In Adults Who Are Anti-Acetylcholine Receptor- Or Anti-Muscle-Specific Tyrosine Kinase Antibody-Positive	219	300	409	491	559	619	671	712	26.40%	Rystiggo is a weekly subcutaneous infusion for adults with generalized myasthenia gravis. It lowers harmful antibodies that disrupt communication between nerves and muscles.
Ngenla	ngenla	Somatrogon-Ghla	somatrogon-ghla	27-Jun-23	27-Jun-35	27-Jun-27	OPKO/PFIZER	Prefilled Injection	24mg and 60mg	Hormonal Therapy	To Treat Growth Failure Due To Inadequate Secretion Of Endogenous Growth Hormone	NA	110	196	255	331	399	457	508	NA	Ngenla is an injection of long-acting growth hormone, administered once a week, for children 3 years and older with growth hormone deficiency. It helps support normal growth using a prefilled pen system.
Beyfortus	beyfortus	Nirsevimab-Alip	nirsevimab-alip	17-Jul-23	17-Jul-35	17-Jul-27	SANOFI	Intramuscular Injection	100mg/ 1ml and 50mg/ 0.5ml	Antiviral	To Prevent Respiratory Syncytial Virus (RSV) Lower Respiratory Tract Disease	2,346	2,606	2,914	3,168	3,382	3,536	3,699	3,862	9.57%	Beyfortus is a single-dose antibody given to newborns and infants to prevent serious RSV (respiratory syncytial virus) lung infections during their first two RSV seasons. It reduces hospitalizations by about 70 to 80%.
Talvey	talvey	Talquetamab-Tgvs	talquetamab-tgvs	09-Aug-23	09-Aug-35	09-Aug-27	JANSSEN BIOTECH, INC.	Subcutaneous Injection	2mg/ml and 40mg/ml	Anticancer	To Treat Adults With Relapsed Or Refractory Multiple Myeloma Who Have Received At Least Four Prior Therapies	287	457	740	1,063	1,391	1,629	1,771	1,959	48.38%	Talvey is a bispecific antibody injection for adults with multiple myeloma who have already tried at least four other treatments. It helps the immune system target and kill myeloma cells.
Elrexfio	elrexfio	Elranatamab-Bcmm	elranatamab-bcmm	14-Aug-23	14-Aug-35	14-Aug-27	PFIZER	Subcutaneous Injection	44mg/1.1ml and 76mg/ 1.9ml	Anticancer	To Treat Adults With Relapsed Or Refractory Multiple Myeloma Who Have Received At Least Four Prior Lines Of Therapy	133	326	469	639	814	972	1,107	1,223	57.29%	Elrexfio is a weekly subcutaneous injection for adults with relapsed or refractory multiple myeloma who have tried at least four prior treatments. Itâs a bispecific antibody that directs T cells to attack myeloma cells by targeting BCMA and CD3.
Veopoz	veopoz	Pozelimab-Bbfg	pozelimab-bbfg	18-Aug-23	18-Aug-35	18-Aug-27	REGENERON PHARMACEUTICALS, INC.	IV Infusion	400mg/2ml	Immunomodulators	To Treat Patients 1 Year Old And Older With CD55-Deficient Protein-Losing Enteropathy (PLE), Also Known As CHAPLE Disease	NA	NA	9	66	153	232	292	332	NA	Veopoz is an antibody injection that treats CHAPLE disease, a rare genetic disorder causing protein loss and chronic intestinal inflammation. It works by blocking complement C5, helping to stabilize protein levels and reduce hospital visits in both children and adults.
Pombiliti	pombiliti	Cipaglucosidase Alfa-Atga	cipaglucosidase-alfa-atga	28-Sep-23	28-Sep-35	28-Sep-27	AMICUS THERAPEUTICS	IV Infusion	105mg/vial	Antimetabolic Disorder	To Treat Late-Onset Pompe Disease	70	113	206	306	402	490	585	679	54.80%	Pombiliti, used with Opfolda (miglustat), treats adults with late-onset Pompe disease who arenât responding to enzyme replacement therapy. It delivers an enzyme to break down muscle-accumulated glycogen, improving muscle strength and lung function.
Bimzelx	bimzelx	Bimekizumab	bimekizumab	17-Oct-23	17-Oct-35	17-Oct-27	UCB INC	Injection	160mg/ml	Immunomodulators	To Treat Moderate To Severe Plaque Psoriasis In Adults Who Are Candidates For Systemic Therapy Or Phototherapy	657	1,465	2,360	3,360	4,206	4,882	5,442	5,922	59.07%	Bimzelx is a subcutaneous injection used to treat plaque psoriasis, psoriatic arthritis, axial spondyloarthritis (including ankylosing spondylitis), and hidradenitis suppurativa. It targets and blocks ILâ17A and ILâ17F cytokines to reduce inflammation and skin/joint symptoms.
Omvoh	omvoh	Mirikizumab-Mrkz	mirikizumab-mrkz	26-Oct-23	26-Oct-35	26-Oct-27	ELI LILLY	IV Infusion	300mg/15ml	Antiulcer	To Treat Ulcerative Colitis	132	291	564	689	819	929	1,026	1,117	57.83%	Omvoh is a once-daily oral antibody for adults with moderately to severely active ulcerative colitis. It targets inflammatory pathways to reduce bowel inflammation and improve symptoms.
Loqtorzi	loqtorzi	Toripalimab-Tpzi	toripalimab-tpzi	27-Oct-23	27-Oct-35	27-Oct-27	COHERUS BIOSCIENCES	IV Infusion	40mg/ml	Anticancer	To Treat Recurrent Or Metastatic Nasopharyngeal Carcinoma When Used Together With Or Following Other Therapies	19	50	75	90	110	130	150	170	55.12%	Loqtorzi is an IV antibody used alongside other treatments for recurrent or metastatic nasopharyngeal carcinoma. It helps the immune system recognize and attack cancer cells.
Ryzneuta	ryzneuta	Efbemalenograstim Alfa-Vuxw	efbemalenograstim-alfa-vuxw	16-Nov-23	16-Nov-35	16-Nov-27	EVIVE BIOTECHNOLOGY	Injection	20MG/ML	Hematopoietic Growth Factor	To Treat Neutropenia	NA	NA	NA	NA	NA	NA	NA	NA	NA	Ryzneuta is an injection that supports white blood cell production in cancer patients undergoing chemotherapy. It helps lower the risk of infection-related complications by boosting the immune system.
Letybo	letybo	Letibotulinumtoxina-Wlbg	letibotulinumtoxina-wlbg	29-Feb-24	29-Feb-36	29-Feb-28	HUGEL, INC.	IM Injection	50 units per vial and 100 units per vial	Dermatologic	To Temporarily Improve The Appearance Of Moderate-To-Severe Glabellar Lines	NA	NA	NA	NA	NA	NA	NA	NA	NA	Letybo is an injectable neurotoxin used to soften frown lines between the eyebrows by temporarily relaxing the muscles responsible. It works by blocking acetylcholine release at the neuromuscular junction, reducing muscle contractions and smoothing wrinkles.
Tevimbra	tevimbra	Tislelizumab-Jsgr	tislelizumab-jsgr	13-Mar-24	13-Mar-36	13-Mar-28	BEIGENE, LTD.	IV Injection	100mg-10ml	Anticancer	To Treat Unresectable Or Metastatic Esophageal Squamous Cell Carcinoma	621	742	872	1,038	1,171	1,268	1,365	1,460	17.18%	Tevimbra contains Tislelizumab, a monoclonal antibody that is indicated for the treatment of unresectable or metastatic small-cell lung cancer and gastric adenocarcinoma in adult patients. It can be given as a first line in combination with other chemotherapeutic agents, and also to patients who have previously received chemotherapy.
Winrevair	winrevair	Sotatercept-Csrk	sotatercept-csrk	26-Mar-24	26-Mar-36	26-Mar-28	MERCK & CO., INC. (MSD)	Subcutaneous Injection	45 mg lyophilized cake or powder, 60 mg lyophilized cake or powder	Antihypertensive	To Treat Pulmonary Arterial Hypertension	419	1,746	2,926	4,145	5,166	6,130	6,946	7,669	87.39%	Winrevair is used to treat adults with pulmonary arterial hypertension (PAH). It helps improve exercise ability, daily functioning, and lowers the risk of the condition getting worse.
Anktiva	anktiva	Nogapendekin Alfa Inbakicept-Pmln	nogapendekin-alfa-inbakicept-pmln	22-Apr-24	22-Apr-36	22-Apr-28	LMMUNITYBIO, INC.	Intravesical Injection	400 mcg-0.4 mL	Anticancer	To Treat Bladder Cancer	14	70	206	520	1,183	2,122	3,579	5,649	203.19%	Anktiva is the first FDA-approved immunotherapy that activates the immune system to treat BCG-unresponsive non-muscle invasive bladder cancer (CIS), offering some patients a lasting complete response.
Imdelltra	imdelltra	Tarlatamab-Dlle	tarlatamab-dlle	16-May-24	16-May-36	16-May-28	AMGEN	Intravenous Infusion	1mg-vial and 10mg-vial	Anticancer	To Treat Extensive Stage Small Cell Lung Cancer	115	536	793	1,044	1,388	1,616	1,688	2,029	86.39%	Imdelltra is used to treat adults with extensive-stage small cell lung cancer (ES-SCLC) that has returned after platinum-based chemotherapy.
Piasky	piasky	Crovalimab-Akkz	crovalimab-akkz	20-Jun-24	20-Jun-36	20-Jun-28	GENENTECH	Intravenous Infusion	340mg-2ml	Immunomodulators	To Treat Paroxysmal Nocturnal Hemoglobinuria	18	110	212	302	379	455	526	592	114.21%	Nemluvio is an injectable antibody for adults suffering from debilitating itch in prurigo nodularis or moderate-to-severe atopic dermatitis. It blocks the ILâ31 receptor to reduce itching and improve skin healing, offering relief within 48 hours.
Kisunla	kisunla	Donanemab-Azbt	donanemab-azbt	02-Jul-24	02-Jul-36	02-Jul-28	ELI LILLY	Intravenous Infusion	350mg- 20ml	Antialzheimer	To Treat Alzheimerâs Disease	9	283	561	711	927	1,182	1,401	1,580	218.57%	Kisunla is used to treat Alzheimerâs disease. It is an FDA-approved treatmentÂ for early symptomatic Alzheimer's disease, including mild cognitive impairment and the mild dementia stage of the condition.
Nemluvio	nemluvio	Nemolizumab-Ilto	nemolizumab-ilto	12-Aug-24	12-Aug-36	12-Aug-28	CHUGAI PHARMACEUTICAL CO., LTD.	Prefilled Pen For Injection	30mg	Immunomodulators	To Treat Prurigo Nodularis	23	239	571	999	1,524	2,062	2,521	3,017	185.31%	Nemluvio is an injectable antibody for adults suffering from debilitating itch in prurigo nodularis or moderate-to-severe atopic dermatitis. It blocks the ILâ31 receptor to reduce itching and improve skin healing, offering relief within 48 hours.
Niktimvo	niktimvo	Axatilimab-Csfr	axatilimab-csfr	14-Aug-24	14-Aug-36	14-Aug-28	INCYTE CORPORATION	Intravenous Infusion	50mg-ml , 9mg- 0.18ml and 22mg-0.44 ml	Immunomodulators	To Treat Chronic Graft-Versus-Host Disease (cGVHD)	NA	103	201	312	432	533	629	698	NA	Niktimvo is an IV antibody treatment for adults and children (â¥ 40 kg) with chronic graftâversusâhost disease whose condition worsened despite at least two prior therapies. It works by blocking CSFâ1R to calm overactive immune cells and reduce symptoms.
Ebglyss	ebglyss	Lebrikizumab-Lbkz	lebrikizumab-lbkz	13-Sep-24	13-Sep-36	13-Sep-28	ELI LILLY	Prefilled Pen Subcutaneous Injection	250mg	Immunomodulators	To Treat Moderate-To-Severe Atopic Dermatitis	79	423	906	1,278	1,694	2,153	2,493	2,819	115.19%	Ebglyss is used to treat moderate-to-severe atopic dermatitis. It addresses the inflammation caused by eczema all over your body, resultingÂ in persistently dry, itchy, and irritated skin.
Hympavzi	hympavzi	Marstacimab-Hncq	marstacimab-hncq	11-Oct-24	11-Oct-36	11-Oct-28	PFIZER	Injection	150mg-ml	Hemostatic Agents	To Prevent Or Reduce Bleeding Episodes Related To Hemophilia A Or B	NA	52	111	161	206	252	294	332	NA	Hympavzi is a subcutaneous antibody given to patients aged 12 and older to prevent bleeding episodes in hemophilia A or B without factor inhibitors. It works by inhibiting the tissue factor pathway to reduce the frequency of bleeds.
Vyloy	vyloy	Zolbetuximab-Clzb	zolbetuximab-clzb	18-Oct-24	18-Oct-36	18-Oct-28	ASTELLAS PHARMA US, INC.	Intravenous Infusion	100mg-vial	Anticancer	To Treat Gastric Or Gastroesophageal Junction Adenocarcinoma	80	302	425	608	765	891	984	1,072	75.85%	Vyloy is used with fluoropyrimidine and platinum-based chemotherapy as the first-line treatment for HER2-negative gastric or gastroesophageal junction cancer, which cannot be removed by surgery or has spread and tests positive for claudin (CLDN)18.2.
Ziihera	ziihera	Zanidatamab-Hrii	zanidatamab-hrii	20-Nov-24	20-Nov-36	20-Nov-28	JAZZ PHARMACEUTICALS	Intravenous Infusion	30mg-vial	Anticancer	To Treat Unresectable Or Metastatic HER2-Positive (IHC 3+) Biliary Tract Cancer	1	29	92	235	376	555	790	981	340.35%	Ziihera is the first and only approved bispecific antibody drug. It treats unresectable or metastatic HER2-positive (IHC 3+) biliary tract cancer. This drug is given to patients who have already received the other chemotherapeutic treatment.
Bizengri	bizengri	Zenocutuzumab-Zbco	zenocutuzumab-zbco	04-Dec-24	04-Dec-36	04-Dec-28	MERUS N.V.	Injection	375MG/18.75ML	Immunomodulators	To Treat Non-Small Cell Lung Cancer And Pancreatic Adenocarcinoma	NA	6	30	100	164	217	260	306	NA	Bizengri is an IV antibody therapy for adults with advanced non-small cell lung cancer or pancreatic cancer driven by NRG1 gene fusions, used after standard treatments fail. It blocks the fusion proteinâs signaling to help shrink tumors and control disease progression
Unloxcyt	unloxcyt	Cosibelimab-Ipdl	cosibelimab-ipdl	13-Dec-24	13-Dec-36	13-Dec-28	CHECKPOINT THERAPEUTICS INC	Injection	300MG/5ML(60MG/ML)	Anticancer	To Treat Cutaneous Squamous Cell Carcinoma	NA	36	74	159	256	402	543	707	NA	Unloxcyt is an IV antiâPD-L1 antibody for adults with advanced or metastatic cutaneous squamous cell carcinoma who are not surgical or radiation candidates. It helps the immune system fight cancer by blocking PD-L1, with a documented response in nearly half of patients.
Alhemo	alhemo	Concizumab-Mtci	concizumab-mtci	20-Dec-24	20-Dec-36	20-Dec-28	NOVO NORDISK INC	Subcutenous Injection	60MG/1.5ML, 150MG/1.5ML and 300MG/3ML	Hemostatic Agents	For Routine Prophylaxis To Prevent Bleeding Episodes In Hemophilia A And B	NA	56	100	145	191	212	226	247	NA	Alhemo is a preventive injection for people with hemophilia A or B with inhibitors, aged 12 and above. It helps reduce and prevent bleeding episodes by regulating the clotting pathway.
Datroway	datroway	Datopotamab Deruxtecan-Dlnk	datopotamab-deruxtecan-dlnk	17-Jan-25	17-Jan-37	17-Jan-29	DAIICHI SANKYO INC	Intravenous Injection	100MG	Anticancer	To Treat Unresectable Or Metastatic, HR-Positive, HER2-Negative Breast Cancer Who Have Received Prior Endocrine-Based Therapy And Chemotherapy For Unresectable Or Metastatic Disease	9	183	644	1,461	2,210	3,035	3,772	4,507	295.86%	Datroway is an antibody-drug conjugate for adults with advanced non-small cell lung cancer that has an EGFR mutation and progressed after standard treatment. It delivers targeted chemotherapy directly to cancer cells to control tumor growth.
Penpulimab-Kcqx	penpulimab-kcqx	Penpulimab-Kcqx	penpulimab-kcqx	23-Apr-25	23-Apr-37	23-Apr-29	AKESO BIOPHARMA CO., LTD	Intravenous Injection	100MG/10ML(10MG/ML)	Anticancer	In Combination With Either Cisplatin Or Carboplatin And Gemcitabine, To Treat Adults With Recurrent Or Metastatic Non-Keratinizing Nasopharyngeal Carcinoma (NPC), Or As A Single Agent While On Or After Platinum-Based Chemotherapy And At Least One Other Prior Line Of Therapy	NA	79	89	101	109	117	127	132	NA	PenpulimabâKcqx is an intravenous PDâ1 inhibitor used with chemotherapy to treat recurrent or metastatic non-keratinizing nasopharyngeal carcinoma. It boosts immune response to help control tumor growth in patients who have progressed after prior therapies.
Imaavy	imaavy	Nipocalimab-Aahu	nipocalimab-aahu	29-Apr-25	29-Apr-37	29-Apr-29	JANSSEN BIOTECH, INC.	Injection	300MG/1.62ML and 1200MG/6.5ML	Immunomodulators	To Treat Generalized Myasthenia Gravis	NA	413	1,031	1,547	2,011	2,514	3,016	3,469	NA	Imaavy is an IV antibody for adults and teens aged 12 and older with generalized myasthenia gravis who test positive for AChR or MuSK antibodies. It targets and blocks the FcRn receptor to reduce harmful autoantibodies and improve muscle strength.
Emrelis	emrelis	Telisotuzumab Vedotin-Tllv	telisotuzumab-vedotin-tllv	14-May-25	14-May-37	14-May-29	ABBVIE INC	Single-Dose Vial	20MG and 100MG	Anticancer	To Treat Locally Advanced Or Metastatic, Non-Squamous Non-Small Cell Lung Cancer (NSCLC) With High C-Met Protein Overexpression After Prior Systemic Therapy	NA	23	99	232	418	576	724	876	NA	Emrelis is an antibodyâdrug conjugate for adults with locally advanced or metastatic non-squamous non-small cell lung cancer overexpressing câMet after prior therapy. It delivers targeted chemotherapy directly to cancer cells to inhibit tumor progression.
Enflonsia	enflonsia	Clesrovimab-Cfor	clesrovimab-cfor	09-Jun-25	09-Jun-37	09-Jun-29	MERCK SHARP & DOHME LLC	Injection	105MG/0.7ML	Immunomodulators	To Prevent Respiratory Syncytial Virus (RSV) Lower Respiratory Tract Disease In Neonates And Infants Who Are Born During Or Entering Their First RSV Season	NA	92	231	444	634	791	922	1,041	NA	ENFLONSIA is a long-acting, preventive monoclonal antibody developed to protect infants against a broad range of respiratory syncytial virus (RSV) disease severity. This includes severe cases that may lead to hospitalization. It is the first and only RSV preventive option that offers a weight-independent, single-dose administration, simplifying protection across all infants regardless of size or gestational age. ENFLONSIA provides consistent, season-long immunity with a convenient, once-per-season approach.
Andembry	andembry	Garadacimab-Gxii	garadacimab-gxii	16-Jun-25	16-Jun-37	16-Jun-29	CSL BEHRING LLC	Subcutaneous Injection	200MG/1.2ML	Hereditary Angioedema Agents	To Prevent Attacks Of Hereditary Angioedema	NA	129	202	256	364	501	531	567	NA	Andembry is a preventive therapy for hereditary angioedema (HAE) in adults and adolescents 12+ years. This selective Factor XIIa inhibitor targets the top of the inflammatory cascade with once-monthly dosing. FDA-approved in June 2025, offering the first monthly prophylactic HAE treatment targeting Factor XIIa.
Lynozyfic	lynozyfic	Linvoseltamab-Gcpt	linvoseltamab-gcpt	02-Jul-25	02-Jul-37	02-Jul-29	REGENERON PHARMACEUTICALS, INC.	Injection	5MG/2ML	Anticancer	To Treat Relapsed Or Refractory Multiple Myeloma After At Least Four Prior Lines Of Therapy, Including A Proteasome Inhibitor, An Immunomodulatory Agent, And An Anti CD38 Monoclonal Antibody	NA	34	127	240	361	477	569	662	NA	Lynozyfic is a monotherapy for adults with relapsed and refractory multiple myeloma after â¥3 prior therapies. This bispecific T-cell engager bridges CD3 on T-cells with BCMA protein on myeloma cells to activate cancer-cell killing. FDA and EMA approved for heavily pretreated patients who have exhausted standard treatment options.
Keytruda Qlex	keytruda-qlex	Pembrolizumab And Berahyaluronidase Alfa-Pmph	pembrolizumab-and-berahyaluronidase-alfa-pmph	19-Sep-25	NA	NA	MERCK SHARP & DOHME LLC	Subcutaneous Injection	395MG/4800UNITS(2.4ML), 790MG/9600UNITS(4.8ML)	Anticancer	To Treat Adult And Pediatric (12 Years And Older) Solid Tumor Indications Approved For The Intravenous Formulation Of Pembrolizumab	NA	NA	1,115	2,437	3,090	3,321	3,334	3,097	NA	Keytruda Qlex is a subcutaneous formulation of pembrolizumab with berahyaluronidase alfa, approved across multiple solid tumor types. It delivers the same efficacy as IV Keytruda with a quick under-the-skin injection, reducing clinic time for patients.

Brand Name	Brand Name Slug	Molecule	Molecule Slug	Approval Date	NCE Date/Market Exclusivity Expiry	NCE-1 Date/Data Exclusivity Expiry	Innovator	Dosage Form	Strength	Therapeutic Category	Usage	Revenue ($M)	Projected Sales By 2025 ($M)	Projected Sales By 2026 ($M)	Projected Sales By 2027 ($M)	Projected Sales By 2028 ($M)	Projected Sales By 2029 ($M)	Projected Sales By 2030 ($M)	Projected Sales By 2031 ($M)	CAGR (%)	Description	Question 1	Answer 1	Question 2	Answer 2	Question 3	Answer 3	Question 4
Leqembi	leqembi	Lecanemab-Irmb	lecanemab-irmb	06-Jan-23	06-Jan-35	06-Jan-27	EISAI INC.	Injection	500 mg/5 mL (100 mg/mL), 200 mg/2 mL (100 mg/mL)	Antialzheimer	To Treat Alzheimer’s Disease	291	791	1,402	2,169	3,063	3,836	4,608	5,279	80.12%	Leqembi is a prescription medicine for early-stage Alzheimer’s disease. It’s a monoclonal antibody that helps reduce amyloid plaques in the brain and is the first treatment of its kind approved in the European Union.	What is Leqembi and how does it work?	Leqembi is a monoclonal antibody treatment for early-stage Alzheimer's disease. It works by targeting and reducing amyloid plaques in the brain, potentially helping to slow cognitive decline in patients with mild cognitive impairment or mild dementia.	Who is eligible for Leqembi treatment?	Leqembi is for patients with early-stage Alzheimer's disease, specifically mild cognitive impairment or mild dementia. Patients must have confirmed elevated beta-amyloid in the brain through testing like PET scans or spinal fluid analysis.	How is Leqembi administered?	Leqembi is given as an IV infusion every two weeks at a healthcare facility. Each session requires medical supervision and regular monitoring by healthcare professionals.	What are the potential side effects and monitoring requirements?
Brenzavvy	brenzavvy	Bexagliflozin	bexagliflozin	20-Jan-23	20-Jan-28	20-Jan-27	THERACOSBIO LLC	Tablet	20mg	Antidiabetic	To Improve Glycemic Control In Adults With Type 2 Diabetes Mellitus As An Adjunct To Diet And Exercise	NA	663	764	845	928	1,015	NA	NA	NA	Brenzavvy is an SGLT2 inhibitor that helps lower your average blood sugar level over 90 to 120 days. It’s FDA-approved to be used alongside diet and exercise to manage blood sugar in adults with type 2 diabetes.
Jaypirca	jaypirca	Pirtobrutinib	pirtobrutinib	27-Jan-23	27-Jan-28	27-Jan-27	LOXO ONCOLOGY INC	Tablet	50mg,100mg	Anticancer	To Treat Relapsed Or Refractory Mantle Cell Lymphoma In Adults Who Have Had At Least Two Lines Of Systemic Therapy, Including A BTK Inhibitor	337	638	922	1,213	1,492	1,959	2,366	2,796	45.06%	Jaypirca is a non-covalent BTK inhibitor used to treat adults with relapsed or refractory mantle cell lymphoma and chronic lymphocytic leukemia after prior treatments. It’s taken orally once daily.
Orserdu	orserdu	Elacestrant	elacestrant	27-Jan-23	27-Jan-28	27-Jan-27	STEMLINE THERAPEUTICS INC	Tablet	EQ 86MG BASE,EQ 345MG BASE	Hormonal Therapy	To Treat Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative, ESR1-Mutated, Advanced Or Metastatic Breast Cancer With Disease Progression Following At Least One Line Of Endocrine Therapy	NA	6	28	58	98	139	174	212	NA	Orserdu is a once-daily selective estrogen receptor degrader (SERD) approved for ER-positive, HER2-negative, ESR1-mutated, advanced or metastatic breast cancer in adults after endocrine therapy.
Jesduvroq	jesduvroq	Daprodustat	daprodustat	01-Feb-23	01-Feb-28	01-Feb-27	GLAXOSMITHKLINE INTELLECTUAL PROPERTY NO 2 LTD ENGLAND	Tablet	1mg,2mg,4mg,6mg,8mg	Antianemic	To Treat Anemia Caused By Chronic Kidney Disease For Adults On Dialysis For At Least Four Months	NA	75	107	134	157	174	185	192	NA	Jesduvroq is an oral HIF-PHI approved for the treatment of anemia in adults with chronic kidney disease on dialysis. It was voluntarily withdrawn in the U.S. for non-safety-related reasons but remains FDA-listed.

***Last Updated : 2025-Sep-08 15:00:00

**Note: Blank records are currently unavailable and will be updated in future versions.

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