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NCE-1 Intelligence & Market Opportunity

Ekterly

Sebetralstat
Hereditary Angioedema Agents
Oral Tablet

Ekterly is the first and only oral, on-demand therapy for hereditary angioedema (HAE) attacks in patients aged 12 and older. It works by inhibiting plasma kallikrein, preventing excessive bradykinin production to reduce swelling rapidly. Approved in the U.S. and U.K. in 2025, Ekterly offers fast relief, convenient oral dosing, and a major advance over injectable treatments, giving patients greater independence and control during acute HAE episodes.

Approval Date
03-Jul-25
NCE-1 Date
03-Jul-29
NCE Date
03-Jul-30
Commercial snapshot

Market performance & projections

Revenue ($M)
49
CAGR (%)
77.83%
Projected sales, 2026–2032 ($M)
Analyst projection, $M per year
2026
176
2027
285
2028
389
2029
490
2030
583
2031
674
2032
758
Molecule profile

Details & specifications

Molecule
Sebetralstat
Innovator
KALVISTA PHARMACEUTICALS LTD
Dosage Form
Oral Tablet
Strength
300 mg
Therapeutic Category
Hereditary Angioedema Agents
Usage
To treat acute attacks of hereditary angioedema
Good to know

Frequently asked questions

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